Experimental Aortic Valve Cusp Extension with CorMatrix in a Porcine Model

Zahra Mosala Nezhad; Alain Poncelet; Caroline Fervaille; Laurent de Kerchove; Pierre Gianello

doi:10.1055/s-0036-1586756

The Thoracic and Cardiovascular Surgeon, Table of Contents

Thorac Cardiovasc Surg 2017; 65(03): 206-210
DOI: 10.1055/s-0036-1586756

Short Communication

Georg Thieme Verlag KG Stuttgart · New York

Experimental Aortic Valve Cusp Extension with CorMatrix in a Porcine Model

Zahra Mosala Nezhad

¹Department of Cardiovascular and Thoracic Surgery, Université Catholique de Louvain, Cliniques Universitaire Saint Luc, Brussels, Belgium

,

Alain Poncelet

¹Department of Cardiovascular and Thoracic Surgery, Université Catholique de Louvain, Cliniques Universitaire Saint Luc, Brussels, Belgium

,

Caroline Fervaille

²Laboratory of Anatomy Pathology, Université Catholique de Louvain, Mont-Godinne Hospital-CHU, Mont-Godinne, Belgium

,

Laurent de Kerchove

¹Department of Cardiovascular and Thoracic Surgery, Université Catholique de Louvain, Cliniques Universitaire Saint Luc, Brussels, Belgium

,

Pierre Gianello

³Division of Experimental Surgery and Transplantation (CHEX), Institute of Experimental and Clinical Research (IREC), Université Catholque de Louvain, Brussels, Belgium

› Author Affiliations

Abstract

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Abstract

Background We tested the feasibility of using porcine small intestinal submucosal extracellular matrix (CorMatrix) for aortic valve (AV) repair in porcine model examining its resorption and remodeling potential.

Methods The non-coronary cusp was replaced with CorMatrix in four animals for 120 days. Valve function was assessed by echocardiography. Explants were examined by histology, immunohistochemistry, and collagen assessment.

Results CorMatrix was almost totally replaced with tissue resembling the native cusp with a partial two-layer architecture. However, function was lost due to thickening and calcification.

Conclusions Tested in high-pressure AV position in a pig model, CorMatrix degrades and remodels, but also loses function.

Keywords

aortic valve - CorMatrix - porcine small intestinal submucosal extracellular matrix

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References

References
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